254 research outputs found

    Clinicopathological determinants of an elevated systemic inflammatory response following elective potentially curative resection for colorectal cancer

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    Introduction: The postoperative systemic inflammatory response (SIR) is related to both long- and short-term outcomes following surgery for colorectal cancer. However, it is not clear which clinicopathological factors are associated with the magnitude of the postoperative SIR. The present study was designed to determine the clinicopathological determinants of the postoperative systemic inflammatory response following colorectal cancer resection. Methods: Patients with a histologically proven diagnosis of colorectal cancer who underwent elective, potentially curative resection during a period from 1999 to 2013 were included in the study (n = 752). Clinicopathological data and the postoperative SIR, as evidenced by postoperative Glasgow Prognostic Score (poGPS), were recorded in a prospectively maintained database. Results: The majority of patients were aged 65 years or older, male, were overweight or obese, and had an open resection. After adjustment for year of operation, a high day 3 poGPS was independently associated with American Society of Anesthesiologists (ASA) grade (hazard ratio [HR] 1.96; confidence interval [CI] 1.25–3.09; p = 0.003), body mass index (BMI) (HR 1.60; CI 1.07–2.38; p = 0.001), mGPS (HR 2.03; CI 1.35–3.03; p = 0.001), and tumour site (HR 2.99; CI 1.56–5.71; p < 0.001). After adjustment for year of operation, a high day 4 poGPS was independently associated with ASA grade (HR 1.65; CI 1.06–2.57; p = 0.028), mGPS (HR 1.81; CI 1.22–2.68; p = 0.003), NLR (HR 0.50; CI 0.26–0.95; p = 0.034), and tumour site (HR 2.90; CI 1.49–5.65; p = 0.002). Conclusions: ASA grade, BMI, mGPS, and tumour site were consistently associated with the magnitude of the postoperative systemic inflammatory response, evidenced by a high poGPS on days 3 and 4, in patients undergoing elective potentially curative resection for colorectal cancer

    Digital Entrepreneurship in China: Insight into Online Business Start-up Among Chinese University Students Based On Entrepreneurial Intention

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    This paper investigates the entrepreneurial intention of Chinese university students to provide insight into digital entrepreneurship. An online survey of 305 university students in Beijing was the basis for the data used to test a logistic regression model of the variables underpinning entrepreneurial intention. Factors determining whether Chinese students intend to engage in digital entrepreneurship were “family business”, “perceived motivations” (especially “Self-achievement”), and “perceived barriers” (especially “Lack of experience”). These are a subset of the antecedent factors influencing entrepreneurship more broadly. The nature of digital entrepreneurship may negate some of the factors, especially culture, that serve as barriers to entrepreneurship in the Chinese context. Although this study is limited by its quantitative methodology and focus on Chinese students attending a single university in Beijing, it contributes to knowledge regarding student engagement with digital entrepreneurship

    Reducing attendances and waits in emergency departments : a systematic review of present innovations

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    Reducing the waits in emergency departments is important for patients and is a government priority. In order to reduce waits the whole system must be considered. The flow of patients before arrival at the emergency department determines the workload of the department. The staffing, resources and systems within the emergency department are key to providing high quality timely care. The flow of patients after leaving the emergency department until their return home will determine whether they can be discharged from the department in a timely manner. Despite the present focus on emergency care in the NHS there have been no reviews of the literature to inform the present changes to reduce waits

    Failure demand: a concept evaluation in UK primary care

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    Purpose: Our purpose was to assess failure demand as a lean concept that assists in waste analysis during quality improvement activity. We assess whether the concept’s limited use is a missed opportunity to help us understand improvement priorities, given that a UK Government requirement for public service managers to report failure demand has been removed. Design/methodology/approach: We look at the literature across the public sector and then apply the failure demand concept to the UK’s primary healthcare system. The UK National Health Service (NHS) demand data are analysed and the impact on patient care is elicited from patient interviews. Findings: The study highlighted the concept’s value, showing how primary care systems often generate failure demand partly owing to existing demand and capacity management practices. This demand is deflected to other systems, such as the accident and emergency department, with a considerable detrimental impact on patient experience. Research implications: More research is needed to fully understand how best to exploit the failure demand concept within wider healthcare as there are many potential barriers to its appropriate and successful application. Practical implications: We highlight three practical barriers to using failure demand: (i) demand within the healthcare system is poorly understood; (ii) systems improvement understanding is limited; and (iii) need to apply the concept for improvement and not just for reporting purposes. Originality/value: We provide an objective and independent insight into failure demand that has not previously been seen in the academic literature, specifically in relation to primary healthcare

    Strengthening school leadership towards improving school resiliency

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    “Strengthening School Leadership Toward Improving School Resiliency” was a two-year interdisciplinary multi-country development research project exploring how the quality of school leadership could be strengthened as a means of improving education quality in under-resourced environments. The primary objective of the project was to understand whether use of a specific continuous improvement approach, Improvement Science (IS), supports sustainable change in the practices of school leaders. School leaders are acknowledged to have a critical role in improving the quality of teaching and learning within schools. Continuous improvement methods such as IS offer a set of ideas, tools and practices which empower practitioners such as school leaders to take an active role in improvement, crafting a narrative which explains the improvement initiative and helping to remove obstacles and blockages in the improvement initiative, and other actions which move the institution towards its goals

    Failure demand: An evaluation of concept in UK Primary Care

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    Purpose: Our purpose was to assess failure demand as a lean concept that assists in waste analysis during quality improvement activity. We assess whether the concept's limited use is a missed opportunity to help understand improvement priorities, given that a UK Government requirement for public service managers to report failure demand has been removed. Design/methodology/approach: We look at the literature across the public sector and then apply the failure demand concept to the UK's primary healthcare system. The UK National Health Service (NHS) demand data are analysed and the impact on patient care is elicited from patient interviews. Findings: The study highlighted the concept's value, showing how primary care systems often generate failure demand partly owing to existing demand and capacity management practices. This demand is deflected to other systems, such as the accident and emergency department, with a considerable detrimental impact on patient experience. Research implications: More research is needed to fully understand how best to exploit the failure demand concept within wider healthcare as there are many potential barriers to its appropriate and successful application. Practical implications: We highlight three practical barriers to using failure demand: (i) poor general understanding of demand within the healthcare system; (ii) limited understanding of systems improvement; and (iii) need to apply the concept for improvement and not just for reporting purposes. Originality/value: We provide an objective and independent insight into failure demand that has not previously been seen in the academic literature, specifically in relation to primary healthcare
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